GoalUrate

• About
• Basics
• Interpretation
• References

About

The GoalUrate is a decision aid tool that determines what the goal uric acid is for a patient with gout who is on or initiating urate-lowering therapy. It is essentially how low providers should aim for the patient's uric acid to be when adjusting the dose of urate-lowering therapy.

Basics

The solubility of uric acid in the blood is 6.8 mg/dL¹. Guidelines recommend aiming for a reasonable amount lower than the solubility limit in order to make sure patients are consistently net negative uric acid.

Interpretation

If the goal uric acid is 6.0 mg/dL, this means that the provider should aim for the patient's uric acid to be 6.0 mg/dL or lower when adjusting the dose of urate-lowering therapy. Similarly, if the goal uric acid is 5.0 mg/dL, this means that the provider should aim for the patient's uric acid to be 5.0 mg/dL or lower when adjusting the dose of urate-lowering therapy.

References

1. Gröbner W, Zöllner N. Uricosuric therapy and urate solubility in blood and urine. Postgrad Med J. 1979;55 Suppl 3:26-31. PMID: 504037.